Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.38 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.38 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275828 | 0.85 | AGTR1 (0.39) | AGTR1AGTR2ABCC3ABCC2 | |
| SCHEMBL7373018 | 0.77 | AGTR1 (0.56) | AGTR1AGTR2ABCC3ABCC2 | |
| SCHEMBL8312872 | 0.73 | AGTR1 (0.55) | AGTR1ABCC3ABCC2 | |
| SCHEMBL8312874 | 0.73 | AGTR1 (0.55) | AGTR1ABCC3ABCC2 | |
| SCHEMBL6959772 | 0.72 | AGTR1 (0.55) | AGTR1 | |
| SCHEMBL7277787 | 0.72 | AGTR1 (0.55) | AGTR1AGTR2ABCC3ABCC2 | |
| SCHEMBL9120725 | 0.72 | AGTR1 (0.41) | AGTR1AGTR2ABCC3ABCC2 | |
| SCHEMBL9280193 | 0.71 | AGTR1 (0.46) | AGTR1AGTR2ABCC3ABCC2 | |
| SCHEMBL9474607 | 0.70 | CNR2 (0.33) | AGTR1AGTR2 | |
| SCHEMBL7276300 | 0.70 | MEN1 (0.34) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0955294-A2 | Imidazolyl-alkenoic acid | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5418250-A | Hypotensive | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-23 | — | — | US | disclosed |
| EP-0425211-B1 | Substituted 5-((tetrazolyl)alkenyl)-imidazoles | SMITHKLINE BEECHAM CORP (US) | 1994-03-30 | — | — | EP | disclosed |
| US-5185351-A | Hypotensive agents; for treatment of congestive heart failure, renal failure and glaucoma | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-09 | — | — | US | disclosed |
| US-5177096-A | Angiotensin II receptor antagonist | SMITHKLINE BEECHAM CORPORATION (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0403159-A2 | Imidazolyl-alkenoic acids | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |