Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | CBFB | Q13951 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636112 | 0.91 | PDE5A (0.41) | PDE5APDE10AKDM4EALDH1A1HPGD | |
| SCHEMBL7280738 | 0.88 | PDE5A (0.50) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL7272064 | 0.83 | PDE5A (0.48) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL7278585 | 0.82 | PDE5A (0.41) | PDE5APDE10AKDM4EALDH1A1HPGD | |
| Isomazole SCHEMBL145963 | 0.81 | PDE5A (0.51) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| Isomazole SCHEMBL30578156 | 0.81 | PDE5A (0.51) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL7278405 | 0.81 | ALDH1A1 (0.39) | PDE5AKDM4EALDH1A1HPGDKDM4C | |
| SCHEMBL7282250 | 0.80 | PDE5A (0.41) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL7274851 | 0.80 | PDE5A (0.41) | PDE5APDE10AKDM4EALDH1A1HPGD | |
| Isomazole SCHEMBL121627 | 0.80 | PDE5A (0.51) | PDE5AKDM4EALDH1A1HPGDPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904785-A | INOTROPIC AGENTS FOR CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4758574-A | 2-phenylimidazio (4,5-c) pyridines | ELI LILLY AND COMPANY (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0093593-A2 | Pyridine compounds | ELI LILLY AND COMPANY (US) | 1983-11-09 | — | — | EP | disclosed |