Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.45 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.45 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27368867 | 0.86 | SLC1A1 (0.50) | ACE2ANPEPRNPEPDNPEPHSD17B10 | |
| SCHEMBL7080776 | 0.83 | CYP1A2 (0.59) | SLC1A1FOLH1 | |
| SCHEMBL7080774 | 0.83 | CYP1A2 (0.59) | SLC1A1FOLH1 | |
| SCHEMBL7080779 | 0.83 | CYP1A2 (0.59) | SLC1A1FOLH1 | |
| SCHEMBL14028935 | 0.81 | APAF1 (0.50) | SLC1A1NPC1RAB9A | |
| SCHEMBL14028939 | 0.81 | APAF1 (0.50) | SLC1A1NPC1RAB9A | |
| SCHEMBL14028933 | 0.81 | APAF1 (0.50) | SLC1A1NPC1RAB9A | |
| SCHEMBL7861189 | 0.81 | CPA1 (0.48) | ANPEPRNPEPDNPEPSLC1A1FOLH1 | |
| SCHEMBL16898377 | 0.81 | NPC1 (0.44) | SLC1A1FOLH1NPC1RAB9A | |
| SCHEMBL16898375 | 0.81 | NPC1 (0.44) | SLC1A1FOLH1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6013792-A | INTERSTITIAL COLLAGENASE INHIBITOR; ANTIARTHRITIC AGENTS, ANTIOSTEOPOROSIS AGENTS | SYNTEX (U.S.A.), INC. (US) | 2000-01-11 | — | — | US | disclosed |
| CN-1040211-C | Matrix metalloprotease inhibitors | SYNTEX INC (US) | 1998-10-14 | — | — | CN | disclosed |
| US-5773428-A | BONE DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0807114-A1 | BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0712403-B1 | MATRIX METALLOPROTEASE INHIBITORS | SYNTEX INC (US) | 1997-09-10 | — | — | EP | disclosed |
| CN-1132511-A | Matrix metalloprotease inhibitors | SYNTEX A INC (US) | 1996-10-02 | — | — | CN | disclosed |
| WO-1996023791-A1 | BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-08-08 | — | — | WO | disclosed |
| EP-0712403-A1 | MATRIX METALLOPROTEASE INHIBITORS | SYNTEX INC (US) | 1996-05-22 | — | — | EP | disclosed |
| WO-1995004735-A1 | MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1995-02-16 | — | — | WO | disclosed |
| US-4996358-A | Control, prevention rheumatic diseases | HOFFMANN-LA ROCHE INC. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0236872-A2 | Hydroxyl amine derivatives, their preparation and use as medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-16 | — | — | EP | disclosed |