Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338034 | 0.95 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7281463 | 0.89 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7272860 | 0.89 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL7278584 | 0.87 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7272788 | 0.87 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL7278375 | 0.85 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL7270989 | 0.84 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7271034 | 0.83 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL7280079 | 0.83 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7272290 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459505-B1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5536730-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATIVE ACTIVITY | KYOWA HAKKO KOGYO CO. LTD. (JP) | 1996-07-16 | — | — | US | disclosed |
| US-5364859-A | Antiinflammatory agents, antiallergens, bronchodilators | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-15 | — | — | US | disclosed |
| EP-0459505-A1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-04 | — | — | EP | disclosed |