Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734007 | 0.86 | ALDH1A1 (0.43) | POLBHTTNPSR1L3MBTL1ACHE | |
| SCHEMBL9641693 | 0.78 | HTR2A (0.54) | HTTNPSR1L3MBTL1ALDH1A1TDP1 | |
| SCHEMBL6719369 | 0.77 | ESR1 (0.42) | NPSR1ACHEALDH1A1TSHRADRA2B | |
| SCHEMBL6486060 | 0.76 | CA1 (0.50) | POLBHTTNPSR1L3MBTL1CA1 | |
| SCHEMBL23356101 | 0.76 | CYP3A4 (0.37) | L3MBTL1ALDH1A1IDO1TDO2TSHR | |
| SCHEMBL9588383 | 0.76 | NISCH (0.41) | L3MBTL1ALDH1A1IDO1TDO2TSHR | |
| SCHEMBL20916740 | 0.76 | TSHR (0.34) | TSHR | |
| SCHEMBL910886 | 0.75 | CA1 (0.48) | POLBHTTNPSR1L3MBTL1CA1 | |
| SCHEMBL11750476 | 0.74 | IDO1 (0.53) | POLBHTTNPSR1L3MBTL1CA1 | |
| SCHEMBL12157085 | 0.74 | HTT (0.53) | POLBHTTNPSR1L3MBTL1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384341-A2 | New proline derivatives | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1990-08-29 | — | — | EP | claimed |
| US-6121311-A | Method for treating cocainism | JAPAN TOBACCO INC. (JP) | 2000-09-19 | — | — | US | disclosed |
| EP-0384341-A2 | New proline derivatives | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1990-08-29 | — | — | EP | disclosed |