Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9387361 | 0.73 | LMNA (0.47) | MAOAMAOBCYP2A6GRM5ALDH1A1 | |
| SCHEMBL73966 | 0.72 | TSHR (0.39) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10916201 | 0.70 | TSHR (0.38) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL235218 | 0.67 | CYP2A6 (0.44) | CYP2A6CYP11B2ALDH1A1HTTMAPT | |
| SCHEMBL7470493 | 0.66 | HSP90AA1 (0.46) | CYP11B2ALDH1A1HTTL3MBTL1NPC1 | |
| SCHEMBL6675291 | 0.66 | MAPT (0.33) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL7267457 | 0.65 | TP53 (0.47) | ALDH1A1MAPTTP53CREBBPLMNA | |
| SCHEMBL13169643 | 0.64 | MAPT (0.33) | ALDH1A1HTTMAPTL3MBTL1RAB9A | |
| SCHEMBL6114715 | 0.64 | CYP2A6 (0.43) | MAOAMAOBCYP2A6CYP11B2GRM5 | |
| SCHEMBL7113456 | 0.63 | HSP90AA1 (0.47) | MAOAALDH1A1HTTMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451538-B1 | Use of pyridoindole derivatives in the treatment of ischemic disorders | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-05-22 | — | — | EP | disclosed |
| EP-0361317-B1 | Pyridoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-04-05 | — | — | EP | disclosed |
| EP-0384349-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1994-04-27 | — | — | EP | disclosed |
| US-5290785-A | Therapeutic agent for ischemic diseases | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-01 | — | — | US | disclosed |
| US-5173493-A | For treatment or prevention of nausea or vomiting | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-12-22 | — | — | US | disclosed |
| US-5141945-A | 5-Hydroxytryptamine antagonists, treatment or prevention of nausea and vomiting | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| EP-0451538-A2 | Use of pyridoindole derivatives in the treatment of ischemic disorders | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-10-16 | — | — | EP | disclosed |
| EP-0361317-A2 | Pyridoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-04-04 | — | — | EP | disclosed |