Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 9/20 | 0.49 |
| ▸ | MME | P08473 | 5/20 | 0.48 |
| ▸ | ANPEP | P15144 | 5/20 | 0.40 |
| ▸ | IL1RN | P18510 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278473 | 1.00 | ACE (0.49) | ACEACE2MMEANPEPIL1RN | |
| SCHEMBL10331861 | 1.00 | ACE (0.49) | ACEACE2MMEANPEPIL1RN | |
| SCHEMBL5669628 | 0.92 | ACE (0.58) | ACEACE2MME | |
| SCHEMBL3726276 | 0.92 | ACE (0.58) | ACEACE2MME | |
| SCHEMBL197902 | 0.92 | ACE (0.58) | ACEACE2MME | |
| SCHEMBL12893385 | 0.92 | ACE (0.58) | ACEACE2MME | |
| SCHEMBL8355311 | 0.80 | ACE (0.60) | ACEACE2MME | |
| SCHEMBL16804559 | 0.79 | ACE (0.47) | ACEACE2MME | |
| SCHEMBL7497338 | 0.79 | ACE (0.49) | ACEACE2MME | |
| SCHEMBL18297189 | 0.78 | ACE (0.40) | ACEACE2MMEANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595610-B1 | Benzo-fused lactams | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | disclosed |
| EP-0595610-A1 | Benzo-fused lactams | E.R. SQUIBB & SONS, INC. (US) | 1994-05-04 | — | — | EP | disclosed |