Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 9/20 | 0.58 |
| ▸ | MME | P08473 | 5/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | GZMB | P10144 | 1/20 | 0.41 |
| ▸ | AADAT | Q8N5Z0 | 5/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3726276 | 1.00 | ACE (0.58) | ACEACE2MMESTAT3GZMB | |
| SCHEMBL5669628 | 1.00 | ACE (0.58) | ACEACE2MMESTAT3GZMB | |
| SCHEMBL12893385 | 1.00 | ACE (0.58) | ACEACE2MMESTAT3GZMB | |
| SCHEMBL10331861 | 0.92 | ACE (0.49) | ACEACE2MME | |
| SCHEMBL7278473 | 0.92 | ACE (0.49) | ACEACE2MME | |
| SCHEMBL7278480 | 0.92 | ACE (0.49) | ACEACE2MME | |
| SCHEMBL16804559 | 0.87 | ACE (0.47) | ACEACE2MMESTAT3GZMB | |
| SCHEMBL7497338 | 0.85 | ACE (0.49) | ACEACE2MMESTAT3GZMB | |
| SCHEMBL27015282 | 0.84 | ACE (0.61) | ACEACE2MMESTAT3GZMB | |
| SCHEMBL14169787 | 0.82 | ACE (0.45) | ACEACE2MMESTAT3GZMB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841257-B2 | Inhibitors of STAT3 and uses thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-09-23 | — | — | US | claimed |
| US-20120035114-A1 | INHIBITORS OF STAT3 AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-02-09 | — | — | US | claimed |
| US-8088890-B2 | Peptides and peptidomimetic compounds, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition | FIBREX MEDICAL RESEARCH & DEVELOPMENT GMBH (AT) | 2012-01-03 | — | — | US | claimed |
| EP-2328925-A1 | PEPTIDES AND PEPTIDOMIMETIC COMPOUNDS, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION | Fibrex Medical Research & Development GmbH (AT) | 2011-06-08 | — | — | EP | claimed |
| EP-2274328-A1 | PEPTIDES, PEPTIDOMIMETICS AND DERIVATIVES THEREOF, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION | Fibrex Medical Research & Development GmbH (AT) | 2011-01-19 | — | — | EP | claimed |
| WO-2010118309-A2 | INHIBITORS OF STAT3 AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-10-14 | — | — | WO | claimed |
| US-20100081787-A1 | PEPTIDES AND PEPTIDOMIMETIC COMPOUNDS, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION | FIBREX MEDICAL RESEARCH & DEVELOPMENT GMBH (AT) | 2010-04-01 | — | — | US | claimed |
| US-7611692-B2 | bombesin, derivatives and/or analogues capable of complexing metal ions, radionuclides or optical labels, for use in radiotherapy | BRACCO IMAGING S.P.A. (IT) | 2009-11-03 | — | — | US | claimed |
| US-20070010428-A1 | Inhibitors of signal transduction and activator of transcription 3 | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2007-01-11 | — | — | US | claimed |
| EP-1616571-A2 | Lysine containing peptides for treatment of heart disease | Ardana Bioscience Limited (GB) | 2006-01-18 | — | — | EP | claimed |
| EP-1082128-B1 | LYSINE CONTAINING PEPTIDES FOR TREATMENT OF HEART DISEASE | ARDANA BIOSCIENCE LTD (GB) | 2005-12-28 | — | — | EP | claimed |
| EP-4153310-B1 | BBETA-15-42 FOR THE TREATMENT OF VIRAL ENDOTHELITIS | F4 PHARMA GMBH (AT) | 2026-02-18 | — | — | EP | disclosed |
| US-20230293640-A1 | COMPOUNDS FOR THE TREATMENT OF ENDOTHELIITIS IN CONTEXT OF VIRALLY CAUSED DISEASES | F4 PHARMA GMBH (AT) | 2023-09-21 | — | — | US | disclosed |
| US-20230257388-A1 | GRANZYME B DIRECTED IMAGING AND THERAPY | CYTOSITE BIOPHARMA INC. (US) | 2023-08-17 | — | — | US | disclosed |
| US-20230257388-A1 | GRANZYME B DIRECTED IMAGING AND THERAPY | CYTOSITE BIOPHARMA INC. (US) | 2023-08-17 | — | — | US | disclosed |
| US-6124263-A | Treatment of tumors by administration of growth hormone releasing compounds and their antagonists | ASTA MEDICA AG (DE) | 2000-09-26 | — | — | US | disclosed |
| US-6025471-A | EXHIBIT BINDING TO CARDIAC TISSUE AND NORMALIZE CARDIAC PRESSURE AFTER ADMINISTRATION, AS WELL AS DIAGNOSTIC AND THERAPEUTIC PROPERTIES FOR CERTAIN NEOPLASTIC TISSUES; PREFERABLY HAVE AT LEAST ONE LYSINE UNIT AND AT LEAST ONE | ARDANA BIOSCIENCE LIMITED (GB) | 2000-02-15 | — | — | US | disclosed |
| US-5932548-A | ANTIISCHEMIC AGENTS USING PEPTIDES | ARDANA BIOSCIENCE LIMITED (GB) | 1999-08-03 | — | — | US | disclosed |
| EP-0706525-A1 | ANTIHYPERTENSIVE TRICYCLIC AZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | Novartis AG (CH) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001353-A1 | ANTIHYPERTENSIVE TRICYCLIC AZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | CIBA-GEIGY AG (CH) | 1995-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257388-A1 | GRANZYME B DIRECTED IMAGING AND THERAPY | GZMB, PRF1, CTSB | ACE 1545/4885ACE2 1260/4885MME 289/4885 |
| US-20230293640-A1 | COMPOUNDS FOR THE TREATMENT OF ENDOTHELIITIS IN CONTEXT OF VIRALLY CAUSED DISEASES | FGB, SERPINC1, ECE1 | ACE 201/4885ACE2 163/4885MME 50/4885 |
| US-20100081787-A1 | PEPTIDES AND PEPTIDOMIMETIC COMPOUNDS, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION | NGLY1, GHRHR, GHSR | ACE 4569/4885ACE2 4370/4885MME 1823/4885 |
| US-20120035114-A1 | INHIBITORS OF STAT3 AND USES THEREOF | STAT3, JAK2, STAT6 | ACE 4461/4885ACE2 4154/4885MME 3313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.