Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5068051 | 0.74 | MEN1 (0.62) | MEN1KMT2ACRBNCYP11B1CYP11B2 | |
| SCHEMBL11025336 | 0.70 | MEN1 (0.65) | MEN1KMT2ACRBNDDB1CYP11B1 | |
| SCHEMBL435141 | 0.70 | MEN1 (0.70) | MEN1KMT2ACRBNDDB1CYP11B1 | |
| SCHEMBL14114321 | 0.69 | MEN1 (0.68) | MEN1KMT2ACRBNDDB1CYP11B1 | |
| SCHEMBL14610310 | 0.69 | MEN1 (0.68) | MEN1KMT2ACRBNDDB1CYP11B1 | |
| SCHEMBL29676340 | 0.69 | KMT2A (0.68) | MEN1KMT2ACRBNDDB1CYP11B1 | |
| SCHEMBL2850811 | 0.69 | MEN1 (0.68) | MEN1KMT2A | |
| SCHEMBL7138979 | 0.69 | KMT2A (0.68) | MEN1KMT2ACRBNDDB1CYP11B1 | |
| SCHEMBL7271469 | 0.69 | KMT2A (1.00) | MEN1KMT2ACRBNCYP11B1CYP11B2 | |
| SCHEMBL10961406 | 0.69 | MEN1 (0.56) | MEN1KMT2ACRBNCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4363762-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-12-14 | — | — | US | disclosed |
| US-4359420-A | HYPOTENSIVE AGENT, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1982-11-16 | — | — | US | disclosed |
| US-4346034-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346032-A | ANTIDOTES TO OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346036-A | ALKYLATION; AMIDATION; TRANQUILIZER ANTAGONIST | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346035-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346030-A | ANTIDOTES FOR OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346031-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346033-A | Thienodiazepinone and benzodiazepinone intermediates | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4316839-A | Imidazodiazepine derivatives | HOFFMAN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0027214-A1 | Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-22 | — | — | EP | disclosed |