Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | TGM2 | P21980 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11686737 | 0.85 | MEN1 (0.50) | MEN1KMT2ATGM2CES1GABRG2 | |
| SCHEMBL435141 | 0.83 | MEN1 (0.70) | MEN1KMT2ALRRK2LMNA | |
| SCHEMBL29676340 | 0.81 | KMT2A (0.68) | MEN1KMT2AGABRG2GABRB3GABRA5 | |
| SCHEMBL14610310 | 0.81 | MEN1 (0.68) | MEN1KMT2ANPC1CYP3A4GRM5 | |
| SCHEMBL11028170 | 0.81 | MEN1 (0.73) | MEN1KMT2AGABRG2GABRB3GABRA5 | |
| SCHEMBL7138979 | 0.81 | KMT2A (0.68) | MEN1KMT2AGABRG2GABRB3GABRA5 | |
| SCHEMBL14114321 | 0.81 | MEN1 (0.68) | MEN1KMT2ATGM2CES1GABRG2 | |
| SCHEMBL11027733 | 0.81 | MEN1 (0.68) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7271469 | 0.81 | KMT2A (1.00) | MEN1KMT2ATGM2CES1AHR | |
| SCHEMBL13150265 | 0.81 | CYP11B1 (0.53) | MEN1KMT2AAHRCMA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130479-A1 | Gabaergic Agents to Treat Memory Deficits | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-05-27 | — | — | US | disclosed |
| US-20100130479-A1 | Gabaergic Agents to Treat Memory Deficits | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-05-27 | — | — | US | disclosed |
| US-20100130479-A1 | Gabaergic Agents to Treat Memory Deficits | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-05-27 | — | — | US | disclosed |
| US-7595395-B2 | Gabaergic agents to treat memory deficits | WISYS TECHNOLOGY FOUNDATION (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595395-B2 | Gabaergic agents to treat memory deficits | WISYS TECHNOLOGY FOUNDATION (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595395-B2 | Gabaergic agents to treat memory deficits | WISYS TECHNOLOGY FOUNDATION (US) | 2009-09-29 | — | — | US | disclosed |
| EP-1888594-A2 | GABAERGIC AGENTS TO TREAT MEMORY DEFICITS | WISYS TECHNOLOGY FOUNDATION, INC. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2007018660-A2 | GABAERGIC IMIDAZOBENZODIAZEPINE DERIVATIVES TO TREAT MEMORY DEFICITS | WISYS TECHNOLOGY FOUNDATION, INC. (US) | 2007-02-15 | — | — | WO | disclosed |
| WO-2007018660-A2 | GABAERGIC IMIDAZOBENZODIAZEPINE DERIVATIVES TO TREAT MEMORY DEFICITS | WISYS TECHNOLOGY FOUNDATION, INC. (US) | 2007-02-15 | — | — | WO | disclosed |
| US-20060258643-A1 | GABAERGIC AGENTS TO TREAT MEMORY DEFICITS | WISYS TECHNOLOGY FOUNDATION, INC. (US) | 2006-11-16 | — | — | US | disclosed |
| US-4346032-A | ANTIDOTES TO OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346034-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346031-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346036-A | ALKYLATION; AMIDATION; TRANQUILIZER ANTAGONIST | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4316839-A | Imidazodiazepine derivatives | HOFFMAN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0027214-A1 | Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-22 | — | — | EP | disclosed |
| US-4031079-A | Intermediates for 2-aminobenzodiazepine-5-ones | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-06-21 | — | — | US | disclosed |
| US-4022767-A | 2-Aminobenzodiazepine-5-ones | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-05-10 | — | — | US | disclosed |
| US-4020055-A | Intermediates for 2-aminobenzodiazepine-5-ones | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-04-26 | — | — | US | disclosed |
| US-4002610-A | 2-Aminobenzodiazepine-5-ones | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130479-A1 | Gabaergic Agents to Treat Memory Deficits | GABRA5, GABRA6, GABRB1 | MEN1 3247/4885KMT2A 396/4885TGM2 1025/4885 |
| US-20060258643-A1 | GABAERGIC AGENTS TO TREAT MEMORY DEFICITS | GABRA5, GABRA6, GABRA1 | MEN1 2769/4885KMT2A 336/4885TGM2 986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.