SCHEMBL7279048

SCHEMBL7279048

COC(=O)C1=C(C)Nc2c(c(C)nn2C)C1c1ccccc1C(F)(F)F

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.57
CYP3A4 P08684 3/20 0.57
ADORA3 P0DMS8 3/20 0.57
MAPT P10636 3/20 0.57
CYP2C9 P11712 3/20 0.57
CYP2C19 P33261 3/20 0.57
CACNA1C Q13936 3/20 0.57
TSHR P16473 2/20 0.57
NFKB1 P19838 2/20 0.57
MEN1 O00255 1/20 0.57
CYP2D6 P10635 1/20 0.57
KMT2A Q03164 1/20 0.57
CACNA1F O60840 1/20 0.56
CACNA1D Q01668 1/20 0.56
CACNA1S Q13698 1/20 0.56
KDM4E B2RXH2 2/20 0.51
ALDH1A1 P00352 2/20 0.51
HPGD P15428 2/20 0.51
GLA P06280 1/20 0.51
GAA P10253 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7271188 0.85 KDM4E (0.44) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL7431449 0.81 CACNA1C (0.78) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL7282056 0.81 CACNA1C (0.67) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL7272617 0.80 CACNA1F (0.57) CACNA1CMEN1KMT2ACACNA1FCACNA1D
SCHEMBL7272107 0.80 GAA (0.48) MAPTTSHRMEN1KMT2AKDM4E
SCHEMBL7280492 0.79 CACNA1C (0.53) CACNA1CCACNA1FCACNA1DCACNA1SACHE
SCHEMBL11004883 0.78 CYP1A2 (0.71) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL31579033 0.78 CACNA1C (0.73) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL10625412 0.78 CYP1A2 (0.71) CYP1A2CYP3A4ADORA3MAPTCYP2C9
Hydrochloric Acid SCHEMBL10629779 0.77 CYP1A2 (0.70) CYP1A2CYP3A4ADORA3MAPTCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0114273-B1 NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES GRUPPO LEPETIT S.p.A. (IT) 1991-11-06 EP disclosed
US-4954508-A HYPOTENSIVE GRUPPO LEPETIT S.P.A. (IT) 1990-09-04 US disclosed