Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.77 |
| ▸ | GBA1 | P04062 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.77 |
| ▸ | TSHR | P16473 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.77 |
| ▸ | USP2 | O75604 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.77 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.77 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.77 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7289619 | 0.99 | PDE5A (0.76) | PDE5AALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7435336 | 0.88 | PDE5A (0.70) | PDE5AALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7286130 | 0.88 | PDE5A (1.00) | PDE5AALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7276945 | 0.85 | CYP1A2 (0.80) | PDE5AALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7277274 | 0.84 | CYP1A2 (1.00) | PDE5AALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7280049 | 0.82 | ALDH1A1 (0.80) | PDE5AALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23579808 | 0.81 | MEN1 (0.51) | PDE5AALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30033670 | 0.81 | MEN1 (0.51) | PDE5AALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL7287894 | 0.81 | ALDH1A1 (0.79) | PDE5AALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1064854 | 0.81 | CYP1A2 (1.00) | PDE5AALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | claimed |
| US-5436233-A | Nervous system disorders | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-07-25 | — | — | US | claimed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | claimed |
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | disclosed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |