Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 8/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7278633 | 0.99 | HTR3A (0.48) | HTR3ACHRNA7CYP1A2CYP2D6CHRM1 | |
| SCHEMBL7272329 | 0.87 | HTR3A (0.54) | HTR3ACHRNA7CHRM1 | |
| Hydrochloric Acid SCHEMBL7272920 | 0.86 | HTR3A (0.53) | HTR3ACHRNA7CHRM1 | |
| SCHEMBL7279675 | 0.85 | HTR3A (0.58) | HTR3ACHRNA7 | |
| SCHEMBL7280683 | 0.85 | HTR3A (0.58) | HTR3ACHRNA7 | |
| Hydrochloric Acid SCHEMBL7272905 | 0.84 | HTR3A (0.57) | HTR3ACHRNA7 | |
| Hydrochloric Acid SCHEMBL7272732 | 0.84 | HTR3A (0.57) | HTR3ACHRNA7 | |
| Hydrochloric Acid SCHEMBL7271486 | 0.82 | CHRNA7 (0.52) | HTR3ACHRNA7CHRM1 | |
| SCHEMBL7281942 | 0.78 | HTR3A (0.58) | HTR3ACHRNA7 | |
| Hydrochloric Acid SCHEMBL7279926 | 0.77 | HTR3A (0.57) | HTR3ACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643923-A | TREATMENT OF ANXIETY, COGNITION ACTIVATORS, SENILITY OR ALZHEIMER'S | SANKYO COMPANY, LIMITED (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0456519-B1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1994-07-13 | — | — | EP | disclosed |
| EP-0456519-A1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1991-11-13 | — | — | EP | disclosed |