Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 7/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13318255 | 0.90 | AHR (0.43) | KCNA5HPGDCYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13118146 | 0.90 | AHR (0.43) | KCNA5HPGDCYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13318256 | 0.90 | AHR (0.43) | KCNA5HPGDCYP2D6CYP2C9CYP2C19 | |
| SCHEMBL27482821 | 0.83 | POLB (0.45) | PKMHPGDPOLBALDH1A1CYP2C9 | |
| SCHEMBL29290745 | 0.82 | POLB (0.47) | PKMPOLBALDH1A1CYP2C19TSHR | |
| SCHEMBL2347309 | 0.82 | HPGD (0.57) | KCNA5HPGDPOLBALDH1A1TSHR | |
| SCHEMBL13616733 | 0.81 | FFAR1 (0.52) | KCNA5POLBALDH1A1 | |
| SCHEMBL28814772 | 0.81 | ALOX5 (0.45) | HPGDPOLBALDH1A1KMT2ANPC1 | |
| SCHEMBL29065807 | 0.81 | ALOX5 (0.45) | HPGDPOLBALDH1A1KMT2ANPC1 | |
| SCHEMBL29065809 | 0.81 | ALOX5 (0.45) | HPGDPOLBALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1048159-C | Imidazolyl-alkenoic acids | SMITHKLINE BEECHAM CORP (US) | 2000-01-12 | — | — | CN | disclosed |
| EP-0955294-A2 | Imidazolyl-alkenoic acid | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5418250-A | Hypotensive | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-23 | — | — | US | disclosed |
| CN-1027504-C | Process for the preparation of imidazolyl-alkenoic acids | SMITHKLINE BEECHAM CORP (US) | 1995-01-25 | — | — | CN | disclosed |
| CN-1079649-A | Preparation contains the method for the pharmaceutical composition of imidazolyl-alkenoic acids | SMITHKLINE BEECHAM CORP (US) | 1993-12-22 | — | — | CN | disclosed |
| US-5185351-A | Hypotensive agents; for treatment of congestive heart failure, renal failure and glaucoma | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-09 | — | — | US | disclosed |
| CN-1048038-A | IMIDAZOLYL-ALKENOIC ACIDS | SMITHKLINE BEECHAM CORP (US) | 1990-12-26 | — | — | CN | disclosed |
| EP-0403159-A2 | Imidazolyl-alkenoic acids | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |