Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27989609 | 0.77 | SRD5A1 (0.50) | CHRNA7ACHE | |
| SCHEMBL19469507 | 0.74 | MTNR1A (0.50) | ACHE | |
| SCHEMBL8943980 | 0.74 | CHRM3 (0.57) | CHRNA7CHRM2CHRM1CHRM3HTR3A | |
| SCHEMBL8944242 | 0.74 | CHRM3 (0.57) | CHRNA7CHRM2CHRM1CHRM3HTR3A | |
| SCHEMBL6846711 | 0.74 | CHRM3 (0.57) | CHRNA7CHRM2CHRM1CHRM3HTR3A | |
| SCHEMBL30311886 | 0.74 | CHRM3 (0.57) | CHRNA7CHRM2CHRM1CHRM3HTR3A | |
| SCHEMBL29013256 | 0.74 | CHRM3 (0.57) | CHRNA7CHRM2CHRM1CHRM3HTR3A | |
| SCHEMBL2996277 | 0.74 | CHRM3 (0.57) | CHRNA7CHRM2CHRM1CHRM3HTR3A | |
| SCHEMBL9597658 | 0.74 | CHRNA7 (0.58) | CHRNA7HTR3AALDH1A1HTR3EHTR3B | |
| SCHEMBL19002290 | 0.73 | MTNR1A (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430190-B1 | New tricyclic compounds | SYNTEX INC (US) | 1995-07-05 | — | — | EP | disclosed |
| EP-0430190-A2 | New tricyclic compounds | SYNTEX (U.S.A.) INC. (US) | 1991-06-05 | — | — | EP | disclosed |