SCHEMBL7279903

SCHEMBL7279903

CCC(C)OC(=O)C1=C(C)Nc2[nH]nc(-c3ccccc3)c2C1c1ccccc1C(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 5/20 0.44
CACNA1F O60840 4/20 0.44
CACNA1D Q01668 4/20 0.44
CACNA1S Q13698 4/20 0.44
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
TSHR P16473 1/20 0.42
CYP2C19 P33261 1/20 0.42
HSD17B10 Q99714 1/20 0.42
ADORA2B P29275 2/20 0.37
ABCB1 P08183 2/20 0.37
TP53 P04637 2/20 0.36
MAPT P10636 2/20 0.36
NR3C2 P08235 2/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
KMT2A Q03164 1/20 0.35
HPGDS O60760 1/20 0.35
ADORA3 P0DMS8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7321724 0.88 CACNA1C (0.43) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL7271011 0.82 CACNA1C (0.44) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL7282249 0.76 CYP2C9 (0.43) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL7270984 0.75 MAPT (0.45) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL7282344 0.73 ACHE (0.55) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL7278351 0.73 CYP2C9 (0.41) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL7270958 0.73 CYP2C9 (0.41) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL7278768 0.73 CACNA1D (0.53) CACNA1CCACNA1FCACNA1DCACNA1STSHR
SCHEMBL7279849 0.73 CACNA1F (0.39) CACNA1CCACNA1FCACNA1DCACNA1STP53
SCHEMBL7282703 0.73 CACNA1F (0.46) CACNA1CCACNA1FCACNA1DCACNA1SMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0114273-B1 NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES GRUPPO LEPETIT S.p.A. (IT) 1991-11-06 EP disclosed
US-4954508-A HYPOTENSIVE GRUPPO LEPETIT S.P.A. (IT) 1990-09-04 US disclosed
EP-0114273-A1 New pharmacologically active pyrazolopyridines GRUPPO LEPETIT S.p.A. (IT) 1984-08-01 EP disclosed