Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.85 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.72 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271311 | 0.96 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7272788 | 0.92 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7281912 | 0.90 | PDE4A (0.87) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7271255 | 0.89 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7271034 | 0.89 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7278584 | 0.89 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7281463 | 0.89 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7273151 | 0.86 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7271125 | 0.86 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| SCHEMBL7278752 | 0.85 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459505-B1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5536730-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATIVE ACTIVITY | KYOWA HAKKO KOGYO CO. LTD. (JP) | 1996-07-16 | — | — | US | disclosed |
| US-5468756-A | Antiinflammatory, antiallergen | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-21 | — | — | US | disclosed |
| US-5364859-A | Antiinflammatory agents, antiallergens, bronchodilators | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-15 | — | — | US | disclosed |
| EP-0459505-A1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-04 | — | — | EP | disclosed |