Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP1A1 | P05023 | 12/20 | 0.68 |
| ▸ | ATP1B1 | P05026 | 12/20 | 0.68 |
| ▸ | ATP1A3 | P13637 | 12/20 | 0.68 |
| ▸ | ATP1B2 | P14415 | 12/20 | 0.68 |
| ▸ | ATP1A2 | P50993 | 12/20 | 0.68 |
| ▸ | ATP1B3 | P54709 | 12/20 | 0.68 |
| ▸ | FXYD2 | P54710 | 12/20 | 0.68 |
| ▸ | ATP1A4 | Q13733 | 12/20 | 0.68 |
| ▸ | TP53 | P04637 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | ATP12A | P54707 | 1/20 | 0.68 |
| ▸ | HBB | P68871 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279884 | 0.91 | ATP1A1 (0.71) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL7276903 | 0.90 | ATP1A1 (0.70) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL7278080 | 0.90 | ATP1A1 (0.63) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL7276870 | 0.89 | ATP1A1 (0.69) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL7279424 | 0.89 | ATP1A1 (0.69) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL7279753 | 0.89 | ATP1A1 (0.69) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL7277089 | 0.87 | ATP1A1 (0.71) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| Oxalic Acid SCHEMBL7286132 | 0.87 | ATP1A1 (0.66) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| Oxalic Acid SCHEMBL7286625 | 0.86 | ATP1A1 (0.65) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL7277854 | 0.86 | ATP1A1 (0.65) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576913-B1 | Digitoxigenin and dihydrodigitoxigenin 3beta-derivatives and pharmaceutical compositions comprising same for the treatment of hypertension. | SIGMA TAU IND FARMACEUTI (IT) | 1997-09-03 | — | — | EP | claimed |
| EP-0576913-A2 | Digitoxigenin and dihydrodigitoxigenin 3beta-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-01-05 | — | — | EP | claimed |
| EP-0576913-B1 | Digitoxigenin and dihydrodigitoxigenin 3beta-derivatives and pharmaceutical compositions comprising same for the treatment of hypertension. | SIGMA TAU IND FARMACEUTI (IT) | 1997-09-03 | — | — | EP | disclosed |
| US-5478817-A | Treatment of hypertension, heart failure | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1995-12-26 | — | — | US | disclosed |
| EP-0576913-A2 | Digitoxigenin and dihydrodigitoxigenin 3beta-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-01-05 | — | — | EP | disclosed |