Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 12/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27329037 | 1.00 | ELANE (0.46) | ELANEHCRTR1HCRTR2DPP4LMNA | |
| SCHEMBL7286287 | 1.00 | ELANE (0.46) | ELANEHCRTR1HCRTR2DPP4LMNA | |
| SCHEMBL7286226 | 0.88 | ELANE (0.45) | ELANE | |
| SCHEMBL9746141 | 0.88 | ELANE (0.44) | ELANE | |
| SCHEMBL27296405 | 0.88 | ELANE (0.45) | ELANE | |
| SCHEMBL7279620 | 0.82 | ELANE (0.51) | ELANE | |
| SCHEMBL7286683 | 0.81 | ELANE (0.49) | ELANE | |
| SCHEMBL7278866 | 0.81 | ELANE (0.44) | ELANEDPP4 | |
| SCHEMBL7276814 | 0.78 | ELANE (0.63) | ELANE | |
| SCHEMBL6860338 | 0.78 | ELANE (0.51) | ELANEHCRTR1HCRTR2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |