Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | NCF1 | P14598 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280272 | 0.80 | PDE5A (0.52) | — | |
| SCHEMBL7297219 | 0.77 | KDM4E (0.33) | HTTALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL8897898 | 0.73 | CYP1A2 (0.68) | APPCYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL24150871 | 0.72 | HTT (0.51) | HTTAPPCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL23723479 | 0.66 | KMT2A (0.70) | APPCYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL26530735 | 0.65 | HTT (0.78) | HTTAPPALDH1A1 | |
| SCHEMBL30378309 | 0.65 | HTT (0.43) | HTTAPPCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL16519501 | 0.64 | CYP1A1 (0.39) | CYP1A2 | |
| SCHEMBL11243280 | 0.64 | APP (0.62) | APPCYP1A2CYP3A4CYP2C19CLK4 | |
| SCHEMBL7494193 | 0.64 | PDE5A (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579496-B1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5439895-A | Cardiovascular disorders; inhibitor of thromboxane A2 synthetase and cyclic guanosine 3',5'-monophosphate | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-08-08 | — | — | US | disclosed |
| US-5436233-A | Nervous system disorders | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0579496-A1 | 4-Aminoquinazoline derivatives, and their use as medicine | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |