Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 5/20 | 0.49 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049498 | 0.90 | SCN2A (0.51) | SCN2AKCNK2FGFR1SCN10ASCN9A | |
| SCHEMBL6049564 | 0.82 | SCN2A (0.54) | SCN2AKCNK2FGFR1SCN10ASCN9A | |
| SCHEMBL168973 | 0.74 | SCN2A (0.57) | SCN2AKCNK2FGFR1SCN10ASCN9A | |
| SCHEMBL30413525 | 0.74 | SCN2A (0.57) | SCN2AKCNK2FGFR1SCN10ASCN9A | |
| SCHEMBL7278590 | 0.74 | SCN2A (0.51) | SCN2AKCNK2FGFR1SCN10ASCN9A | |
| SCHEMBL15914195 | 0.72 | SCN2A (0.49) | SCN2AKCNK2FGFR1SCN10ASCN9A | |
| SCHEMBL6049521 | 0.71 | SCN2A (0.54) | SCN2AKCNK2FGFR1SCN10ASCN9A | |
| SCHEMBL132945 | 0.69 | SCN2A (0.77) | SCN2AKCNK2SCN9ALMNAMAPT | |
| SCHEMBL21657680 | 0.68 | DHFR (0.39) | MERTKADORA1 | |
| SCHEMBL7272688 | 0.68 | SCN2A (0.77) | SCN2AKCNK2SCN10ASCN9ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679645-A1 | Pharmacologically active CNS pyridmidin compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-02 | — | — | EP | disclosed |
| EP-0459819-A2 | Pharmacologically active CNS compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |