SCHEMBL7280792

SCHEMBL7280792

CC(C)(C)N(C(=O)O)c1c2c(nc3ccccc13)CCC(=CCCCCCC1CCN(Cc3ccccc3)CC1)C2=O

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACHE P22303 12/20 0.40
BCHE P06276 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7272609 0.97 ACHE (0.40) ACHEBCHE
SCHEMBL7280009 0.95 ACHE (0.41) ACHEBCHE
SCHEMBL7284054 0.92 ACHE (0.40) ACHE
SCHEMBL7274036 0.87 ACHE (0.39) ACHE
SCHEMBL7274685 0.86 ACHE (0.45) ACHEBCHE
SCHEMBL7281844 0.84 ACHE (0.40) ACHEBCHE
SCHEMBL7284010 0.84 ACHE (0.43) ACHE
SCHEMBL7283210 0.83 ACHE (0.43) ACHE
Hydrochloric Acid SCHEMBL7272630 0.83 MEN1 (0.43) ACHEBCHE
Hydrochloric Acid SCHEMBL7272627 0.83 MEN1 (0.43) ACHEBCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0481429-B1 Quinoline derivatives SS PHARMACEUTICAL CO (JP) 2001-01-24 EP disclosed
EP-0987262-A1 Quinoline derivatives SS PHARMACEUTICAL CO., LTD. (JP) 2000-03-22 EP disclosed
US-5300517-A Treating Alzheimer's SS PHARMACEUTICAL CO., LTD. (JP) 1994-04-05 US disclosed
US-5240934-A Cognition activators SS PHARMACEUTICAL CO., LTD. (JP) 1993-08-31 US disclosed
US-5190951-A Inhibitors of acetylcholinesterase, treatment of senile dementia SS PHARMACEUTICAL CO., LTD. (JP) 1993-03-02 US disclosed
EP-0481429-A2 Quinoline derivatives SS PHARMACEUTICAL CO., LTD. (JP) 1992-04-22 EP disclosed