Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1268381 | 0.84 | ALDH1A1 (0.54) | CYP3A4CYP2C19KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL1710699 | 0.82 | ALDH1A1 (0.52) | CYP3A4CYP2C19KMT2ABRD4ALDH1A1 | |
| SCHEMBL3123091 | 0.82 | ALDH1A1 (0.51) | CYP3A4CYP2C19KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL9462245 | 0.82 | ALDH1A1 (0.51) | CYP3A4CYP2C19KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL1269684 | 0.80 | CYP3A4 (0.67) | CYP3A4CYP2C19KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL4095420 | 0.78 | SMN1; SMN2 (0.73) | CYP3A4CYP2C19KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL1710890 | 0.78 | ALDH1A1 (0.65) | CYP3A4CYP2C19KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7273770 | 0.78 | CYP3A4 (0.55) | CYP3A4CYP2C19KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL8348748 | 0.77 | GRM2 (0.56) | CYP3A4CYP2C19KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL15415933 | 0.77 | ALDH1A1 (0.64) | CYP3A4CYP2C19KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |