Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.42 |
| ▸ | ACE | P12821 | 9/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 9/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287988 | 0.89 | MME (0.41) | MMEACEACE2ALDH1A1 | |
| SCHEMBL7287999 | 0.89 | MME (0.41) | MMEACEACE2ALDH1A1 | |
| SCHEMBL7287502 | 0.84 | ACE (0.44) | MMEACEACE2STAT3 | |
| SCHEMBL7288010 | 0.75 | MME (0.55) | MMEACEACE2STAT3ALDH1A1 | |
| SCHEMBL7287578 | 0.69 | ACE (0.61) | MMEACEACE2STAT3 | |
| SCHEMBL12893385 | 0.68 | ACE (0.58) | MMEACEACE2STAT3 | |
| SCHEMBL5669628 | 0.68 | ACE (0.58) | MMEACEACE2STAT3 | |
| SCHEMBL197902 | 0.68 | ACE (0.58) | MMEACEACE2STAT3 | |
| SCHEMBL3726276 | 0.68 | ACE (0.58) | MMEACEACE2STAT3 | |
| SCHEMBL27015282 | 0.65 | ACE (0.61) | MMEACEACE2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595610-B1 | Benzo-fused lactams | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5504080-A | Benzo-fused lactams | BRISTOL-MYERS SQUIBB CO. (US) | 1996-04-02 | — | — | US | disclosed |
| EP-0595610-A1 | Benzo-fused lactams | E.R. SQUIBB & SONS, INC. (US) | 1994-05-04 | — | — | EP | disclosed |