Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | LIPC | P11150 | 1/20 | 0.30 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431588 | 0.89 | GBA1 (0.41) | GBA1SMN1; SMN2NPC1NAAAEPHX2 | |
| SCHEMBL7977377 | 0.88 | GBA1 (0.41) | GBA1SMN1; SMN2NAAAEPHX2TSHR | |
| SCHEMBL2606649 | 0.87 | — | — | |
| SCHEMBL191351 | 0.87 | NPC1 (0.45) | GBA1SMN1; SMN2NPC1NAAAEPHX2 | |
| SCHEMBL8642669 | 0.85 | GBA1 (0.45) | GBA1NAAAEPHX2TSHR | |
| SCHEMBL11940413 | 0.85 | NPC1 (0.48) | GBA1SMN1; SMN2NPC1NAAAEPHX2 | |
| SCHEMBL6378525 | 0.85 | NPC1 (0.48) | GBA1SMN1; SMN2NPC1NAAAEPHX2 | |
| SCHEMBL9128366 | 0.85 | NPC1 (0.48) | GBA1SMN1; SMN2NPC1NAAAEPHX2 | |
| SCHEMBL192534 | 0.85 | NPC1 (0.48) | GBA1SMN1; SMN2NPC1NAAAEPHX2 | |
| SCHEMBL27915053 | 0.85 | NPC1 (0.48) | GBA1SMN1; SMN2NPC1NAAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320006-A2 | Uses of 1,4-dihydropyridines | LABORATOIRES SYNTEX (FR) | 1989-06-14 | — | — | EP | disclosed |
| US-4761420-A | CARDIOVASCULAR DISORDERS | LABORATOIRES SYNTEX S.A. (FR) | 1988-08-02 | — | — | US | disclosed |
| EP-0249245-A2 | Antihypertensive dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1987-12-16 | — | — | EP | disclosed |