Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.56 |
| ▸ | CCND1 | P24385 | 5/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.56 |
| ▸ | CCND3 | P30281 | 5/20 | 0.56 |
| ▸ | PDE5A | O76074 | 3/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635782 | 0.86 | PDE5A (0.44) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL7270959 | 0.86 | PDE2A (0.58) | PDE5APDE3BPDE3AKDRKDM4E | |
| SCHEMBL7270925 | 0.86 | PDE5A (0.56) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL9634329 | 0.85 | PDE5A (0.55) | CDK4CCNA2CCND1CDK2CCND3 | |
| Hydrochloric Acid SCHEMBL7272531 | 0.85 | PDE2A (0.57) | PDE5APDE3BPDE3AKDRKDM4E | |
| SCHEMBL10415615 | 0.85 | PDE5A (0.57) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL10762876 | 0.85 | PDE5A (0.55) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL7270233 | 0.85 | PDE5A (0.55) | PDE5APDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL10675183 | 0.84 | PDE5A (0.51) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL7272579 | 0.84 | PDE5A (0.56) | CDK4CCNA2CCND1CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0155094-A1 | 2-Arylimidazo(4,5-c)pyridines | ELI LILLY AND COMPANY (US) | 1985-09-18 | — | — | EP | claimed |
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4904785-A | INOTROPIC AGENTS FOR CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4758574-A | 2-phenylimidazio (4,5-c) pyridines | ELI LILLY AND COMPANY (US) | 1988-07-19 | — | — | US | disclosed |
| US-4696931-A | CARDIOVASCULAR DISORDERS, CARDIOTONIC AGENTS | DR. KARL THOMAE GMBH (DE) | 1987-09-29 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| US-4582837-A | Imidazo[4,5-b] and [4,5-c]pyridine derivatives having cardiotonic activity | DR. KARL THOMAE GMBH (DE) | 1986-04-15 | — | — | US | disclosed |
| EP-0155094-A1 | 2-Arylimidazo(4,5-c)pyridines | ELI LILLY AND COMPANY (US) | 1985-09-18 | — | — | EP | disclosed |
| EP-0098448-A2 | Imidazole derivatives, their preparation and medicines containing these compounds | Dr. Karl Thomae GmbH (DE) | 1984-01-18 | — | — | EP | disclosed |
| EP-0093593-A2 | Pyridine compounds | ELI LILLY AND COMPANY (US) | 1983-11-09 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |