SCHEMBL7282183

SCHEMBL7282183

CSc1cccc2nc3c(c(O)c12)C(=O)N(CCC1CCN(Cc2ccccc2)CC1)C3

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACHE P22303 14/20 0.49
PARP1 P09874 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7274681 0.91 ACHE (0.48) ACHEPARP1
SCHEMBL7283958 0.89 ACHE (0.47) ACHE
SCHEMBL7281953 0.85 ACHE (0.57) ACHE
SCHEMBL7281640 0.80 ACHE (0.51) ACHE
SCHEMBL7274846 0.80 ACHE (0.56) ACHE
SCHEMBL7273759 0.79 ACHE (0.51) ACHEPARP1
SCHEMBL7274924 0.79 ACHE (0.57) ACHE
SCHEMBL7274549 0.79 ACHE (0.52) ACHE
SCHEMBL7274684 0.78 ACHE (0.56) ACHE
SCHEMBL4493576 0.78 ACHE (0.56) ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0481429-B1 Quinoline derivatives SS PHARMACEUTICAL CO (JP) 2001-01-24 EP disclosed
EP-0987262-A1 Quinoline derivatives SS PHARMACEUTICAL CO., LTD. (JP) 2000-03-22 EP disclosed
US-5300517-A Treating Alzheimer's SS PHARMACEUTICAL CO., LTD. (JP) 1994-04-05 US disclosed
US-5240934-A Cognition activators SS PHARMACEUTICAL CO., LTD. (JP) 1993-08-31 US disclosed
US-5190951-A Inhibitors of acetylcholinesterase, treatment of senile dementia SS PHARMACEUTICAL CO., LTD. (JP) 1993-03-02 US disclosed
EP-0481429-A2 Quinoline derivatives SS PHARMACEUTICAL CO., LTD. (JP) 1992-04-22 EP disclosed