Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | CTSG | P08311 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281838 | 0.92 | HRH3 (0.44) | HRH3S1PR1HDAC1EPHX2ADRB2 | |
| Hydrochloric Acid SCHEMBL7282229 | 0.91 | HRH3 (0.43) | HRH3S1PR1HDAC1EPHX2ADRB2 | |
| Hydrochloric Acid SCHEMBL8910783 | 0.90 | SIRT2 (0.40) | HRH3S1PR1HDAC1ITGB3ITGA2B | |
| SCHEMBL7282587 | 0.90 | CYP4F2 (0.50) | S1PR1HDAC1ITGB3ITGA2BMAPT | |
| Propylamine SCHEMBL8911200 | 0.89 | S1PR1 (0.44) | HRH3S1PR1HDAC1MAPTCYP4F2 | |
| SCHEMBL27397736 | 0.88 | MEN1 (0.51) | HRH3S1PR1HDAC1TP53CTSG | |
| Hydrochloric Acid SCHEMBL7272819 | 0.86 | HRH3 (0.44) | HRH3S1PR1HDAC1EPHX2ADRB2 | |
| SCHEMBL7280993 | 0.86 | HDAC1 (0.46) | HRH3S1PR1HDAC1MAPT | |
| SCHEMBL7283131 | 0.86 | HRH3 (0.43) | HRH3S1PR1HDAC1EPHX2ADRB2 | |
| SCHEMBL7272906 | 0.86 | F10 (0.42) | HRH3S1PR1HDAC1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |