Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274200 | 0.88 | HDAC1 (0.43) | HDAC1KMT2AALDH1A1HRH3S1PR1 | |
| SCHEMBL7274204 | 0.88 | HDAC1 (0.43) | HDAC1KMT2AALDH1A1HRH3S1PR1 | |
| SCHEMBL27397736 | 0.87 | MEN1 (0.51) | HDAC1KMT2AALDH1A1HRH3S1PR1 | |
| SCHEMBL7281838 | 0.86 | HRH3 (0.44) | HDAC1MAPTHRH3S1PR1 | |
| SCHEMBL7283243 | 0.86 | HRH3 (0.44) | HDAC1MAPTHRH3S1PR1 | |
| Hydrochloric Acid SCHEMBL7272547 | 0.85 | ITGB3 (0.53) | HDAC1HRH3 | |
| SCHEMBL7283797 | 0.85 | HDAC1 (0.43) | HDAC1MAPTHRH3S1PR1 | |
| Hydrochloric Acid SCHEMBL7282229 | 0.85 | HRH3 (0.43) | HDAC1MAPTHRH3S1PR1 | |
| SCHEMBL7283131 | 0.85 | HRH3 (0.43) | HDAC1MAPTHRH3S1PR1L3MBTL1 | |
| SCHEMBL7274577 | 0.84 | HDAC1 (0.42) | HDAC1ALDH1A1MAPTHRH3S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852192-A | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1998-12-22 | — | — | US | disclosed |
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| EP-0503548-B1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-06-04 | — | — | EP | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |
| EP-0503548-A1 | Cyclic urea derivatives, medicaments contaning them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |