Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364845 | 0.93 | REN (0.54) | REN | |
| SCHEMBL7283620 | 0.93 | REN (0.58) | REN | |
| SCHEMBL7283229 | 0.93 | REN (0.60) | REN | |
| SCHEMBL9227669 | 0.93 | REN (0.60) | REN | |
| SCHEMBL7305156 | 0.92 | REN (0.65) | REN | |
| SCHEMBL7295267 | 0.90 | REN (0.61) | REN | |
| SCHEMBL7363731 | 0.90 | REN (0.57) | REN | |
| SCHEMBL7305350 | 0.89 | REN (0.56) | REN | |
| Hydrochloric Acid SCHEMBL7357996 | 0.89 | REN (0.56) | REN | |
| SCHEMBL7281295 | 0.88 | REN (0.69) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389616-A | Renin inhibitor, hypotensive agent | HOFFMAN-LAROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5256645-A | Renin inhibitors; hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5134123-A | Renin enzyme inhibitors for cardiovascular disorders and high blood pressure | HOFFMAN-LA ROCHE INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0332008-A2 | Peptide-like aminoacid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-09-13 | — | — | EP | disclosed |