Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CTRC | Q99895 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315228 | 0.90 | NPC1 (0.53) | NPC1RAB9AMAOBCASP3POLB | |
| SCHEMBL948055 | 0.88 | NPC1 (0.53) | NPC1RAB9AMAOBCASP3POLB | |
| SCHEMBL949772 | 0.88 | NPC1 (0.51) | NPC1RAB9AMAOBCASP3POLB | |
| SCHEMBL7342183 | 0.87 | NPC1 (0.56) | NPC1RAB9AMAOBCASP3POLB | |
| SCHEMBL4416727 | 0.82 | NPC1 (0.62) | NPC1RAB9AMAOBCASP3POLB | |
| SCHEMBL5113764 | 0.81 | NPC1 (0.54) | NPC1RAB9AMAOBCASP3POLB | |
| SCHEMBL6556065 | 0.81 | NPC1 (0.53) | NPC1RAB9AMAOBCASP3POLB | |
| SCHEMBL7201414 | 0.77 | MAOB (0.59) | NPC1RAB9AMAOBCASP3POLB | |
| SCHEMBL7276713 | 0.76 | ENPP2 (0.47) | NPC1RAB9AMAOBCASP3POLB | |
| SCHEMBL473221 | 0.76 | NPC1 (0.61) | NPC1RAB9AMAOBCASP3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |