Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283305 | 1.00 | HPGD (0.48) | HPGDKDM4EPKMRECQLEPHX1 | |
| SCHEMBL1772649 | 0.86 | EPHX1 (0.46) | HPGDKDM4EPKMRECQLEPHX1 | |
| SCHEMBL1498949 | 0.86 | EPHX1 (0.46) | HPGDKDM4EPKMRECQLEPHX1 | |
| SCHEMBL1772647 | 0.86 | EPHX1 (0.46) | HPGDKDM4EPKMRECQLEPHX1 | |
| SCHEMBL10190477 | 0.83 | HPGD (0.49) | HPGDKDM4EPKMRECQLEPHX1 | |
| SCHEMBL10154181 | 0.83 | HPGD (0.49) | HPGDKDM4EPKMRECQLEPHX1 | |
| SCHEMBL7446544 | 0.82 | FAAH (0.43) | HPGDKDM4EPKMRECQLEPHX1 | |
| SCHEMBL1186709 | 0.82 | HPGD (0.48) | HPGDKDM4EPKMRECQLEPHX1 | |
| SCHEMBL12873541 | 0.82 | HPGD (0.48) | HPGDKDM4EPKMRECQLEPHX1 | |
| SCHEMBL12873549 | 0.82 | HPGD (0.48) | HPGDKDM4EPKMRECQLEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0478363-B1 | Novel sulfonamide fibrinogen receptor antagonists | MERCK & CO INC (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0743302-A2 | Sulfonamide fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5294616-A | Anticoagulants, inhibition of fibrinogen binding to blood platelets | MERCK & CO., INC. (US) | 1994-03-15 | — | — | US | disclosed |
| WO-1993019046-A1 | NOVEL SULFONAMIDE FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1993-09-30 | — | — | WO | disclosed |
| EP-0478363-A2 | Novel sulfonamide fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1992-04-01 | — | — | EP | disclosed |