Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 7/20 | 0.42 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284141 | 1.00 | GRIK1 (0.42) | GRIK1KISS1RGRIK2MAPTGRIA2 | |
| SCHEMBL7276283 | 0.80 | GRIK1 (0.47) | GRIK1KISS1RGRIK2GRIA2GRIA4 | |
| SCHEMBL7276287 | 0.80 | GRIK1 (0.47) | GRIK1KISS1RGRIK2GRIA2GRIA4 | |
| SCHEMBL7278350 | 0.78 | GRIK1 (0.42) | GRIK1KISS1RGRIK2GRIA2GRIA4 | |
| SCHEMBL7279080 | 0.78 | GRIK1 (0.42) | GRIK1KISS1RGRIK2GRIA2GRIA4 | |
| SCHEMBL7049062 | 0.74 | GRIK1 (0.62) | GRIK1KISS1RGRIK2GRIA2GRIA4 | |
| SCHEMBL11662516 | 0.74 | GRIK1 (0.62) | GRIK1KISS1RGRIK2GRIA2GRIA4 | |
| SCHEMBL4556871 | 0.74 | GRIK1 (0.69) | GRIK1KISS1RGRIK2GRIA2GRIA4 | |
| SCHEMBL8515594 | 0.74 | GRIK1 (0.62) | GRIK1KISS1RGRIK2GRIA2GRIA4 | |
| SCHEMBL7168755 | 0.74 | GRIK1 (0.48) | GRIK1KISS1RGRIK2GRIA2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5109000-A | THIOL CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS COLLAGENASE INHIBITOR | BEECHAM GROUP P.L.C. (GB) | 1992-04-28 | — | — | US | disclosed |
| EP-0273689-B1 | DERIVATIVES OF N-(2-ALKYL-3-MERCAPTO-GLUTARYL) ALPHA-AMINO ACIDS AND THEIR USE AS COLLAGENASE INHIBITORS | BEECHAM GROUP PLC (GB) | 1991-11-27 | — | — | EP | disclosed |
| US-4937243-A | TREATING CONNECTIVE TISSUE DISEASES | BEECHAM GROUP P.L.C. (GB) | 1990-06-26 | — | — | US | disclosed |
| EP-0273689-A2 | Derivatives of N-(2-alkyl-3-mercapto-glutaryl) alpha-amino acids and their use as collagenase inhibitors | BEECHAM GROUP PLC (GB) | 1988-07-06 | — | — | EP | disclosed |