Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 7/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278350 | 1.00 | GRIK1 (0.42) | GRIK1GRIK2MMP1MMP2MMP3 | |
| SCHEMBL7347433 | 0.84 | GRIK1 (0.41) | GRIK1GRIK2MMP1MMP2MMP3 | |
| SCHEMBL7347429 | 0.84 | GRIK1 (0.41) | GRIK1GRIK2MMP1MMP2MMP3 | |
| SCHEMBL7276283 | 0.80 | GRIK1 (0.47) | GRIK1GRIK2KISS1RGRIA2GRIA4 | |
| SCHEMBL7276287 | 0.80 | GRIK1 (0.47) | GRIK1GRIK2KISS1RGRIA2GRIA4 | |
| SCHEMBL7284141 | 0.78 | GRIK1 (0.42) | GRIK1GRIK2KISS1RGRIA2GRIA4 | |
| SCHEMBL7284138 | 0.78 | GRIK1 (0.42) | GRIK1GRIK2KISS1RGRIA2GRIA4 | |
| SCHEMBL4317765 | 0.76 | GRIK1 (0.41) | GRIK1GRIK2KISS1RGRIA2GRIA4 | |
| SCHEMBL7285916 | 0.75 | ALDH1A1 (0.49) | MMP9ALDH1A1TDP1 | |
| SCHEMBL7285911 | 0.75 | ALDH1A1 (0.49) | MMP9ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552264-A1 | N-(2-ALKYL-3-MERCAPTOGLUTARYL)-AMINO-DIAZA CYCLOALKANONE DERIVATIVES AND THEIR USE AS COLLAGENASE INHIBITORS | BEECHAM GROUP plc (GB) | 1993-07-28 | — | — | EP | disclosed |
| US-5190937-A | Collagenase Inhibitors | BEECHAM GROUP P.L.C. (GB) | 1993-03-02 | — | — | US | disclosed |
| WO-1992006966-A1 | N-(2-ALKYL-3-MERCAPTOGLUTARYL)-AMINO-DIAZA CYCLOALKANONE DERIVATIVES AND THEIR USE AS COLLAGENASE INHIBITORS | BEECHAM GROUP PLC (GB) | 1992-04-30 | — | — | WO | disclosed |
| US-5109000-A | THIOL CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS COLLAGENASE INHIBITOR | BEECHAM GROUP P.L.C. (GB) | 1992-04-28 | — | — | US | disclosed |
| EP-0273689-B1 | DERIVATIVES OF N-(2-ALKYL-3-MERCAPTO-GLUTARYL) ALPHA-AMINO ACIDS AND THEIR USE AS COLLAGENASE INHIBITORS | BEECHAM GROUP PLC (GB) | 1991-11-27 | — | — | EP | disclosed |
| EP-0438223-A1 | N-(2-oxoazacycloalkyl) glutarylamide derivatives and their use as collagenase inhibitors | Beecham Group p.l.c. (GB) | 1991-07-24 | — | — | EP | disclosed |
| US-4937243-A | TREATING CONNECTIVE TISSUE DISEASES | BEECHAM GROUP P.L.C. (GB) | 1990-06-26 | — | — | US | disclosed |
| EP-0273689-A2 | Derivatives of N-(2-alkyl-3-mercapto-glutaryl) alpha-amino acids and their use as collagenase inhibitors | BEECHAM GROUP PLC (GB) | 1988-07-06 | — | — | EP | disclosed |