Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ACE | P12821 | 3/20 | 0.50 |
| ▸ | F2 | P00734 | 3/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7292202 | 0.88 | CYP1A2 (0.49) | MEN1NPC1RAB9AKMT2AACE | |
| SCHEMBL8994558 | 0.88 | MEN1 (0.56) | MEN1NPC1RAB9AKMT2AACE | |
| SCHEMBL13763519 | 0.88 | MEN1 (0.56) | MEN1NPC1RAB9AKMT2AACE | |
| SCHEMBL9257303 | 0.87 | MEN1 (0.52) | MEN1NPC1RAB9AKMT2AACE | |
| SCHEMBL7330019 | 0.83 | MEN1 (0.63) | MEN1NPC1RAB9AKMT2AACE | |
| SCHEMBL5741647 | 0.83 | MEN1 (0.63) | MEN1NPC1RAB9AKMT2AACE | |
| SCHEMBL5741652 | 0.83 | MEN1 (0.63) | MEN1NPC1RAB9AKMT2AACE | |
| SCHEMBL7279154 | 0.83 | MEN1 (0.54) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7284566 | 0.83 | NPC1 (0.63) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL7283530 | 0.80 | MEN1 (0.51) | MEN1NPC1RAB9AKMT2AACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537802-A2 | N-acylpyrrolidines and N-acylthiazolidines, process for their preparation and their use for prevention and/or treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-04-21 | — | — | EP | claimed |
| EP-0345428-A1 | Anti-amnesic pyrrolidine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-12-13 | — | — | EP | claimed |
| US-5411974-A | Thiazoline derivatives, treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-05-02 | — | — | US | disclosed |
| US-5401760-A | Thiazoline derivative for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-03-28 | — | — | US | disclosed |