⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295473 | 0.86 | — | — | |
| SCHEMBL31379789 | 0.81 | ACHE (0.68) | — | |
| SCHEMBL514302 | 0.81 | — | — | |
| Ammonia Solution, Strong SCHEMBL28983308 | 0.79 | EPHX1 (0.79) | — | |
| SCHEMBL3462778 | 0.79 | — | — | |
| SCHEMBL13942586 | 0.77 | — | — | |
| SCHEMBL27912158 | 0.77 | — | — | |
| SCHEMBL18479704 | 0.77 | — | — | |
| SCHEMBL514301 | 0.77 | — | — | |
| SCHEMBL7284973 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822931-B1 | PIPERAZINONES USEFUL AS INHIBITORS OF PLATELET AGGREGATION | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-03-27 | — | — | EP | disclosed |
| US-6020334-A | Piperazinones, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-01 | — | — | US | disclosed |
| US-5935963-A | (4-GUANIDINOBENZOYLAMINO)ACETYL-3-(3-(4-GUANIDINOBENZOYLAMINO) PROPYL)-2-OXOPIPERAZINE-1-ACETIC ACID OR A SALT; CONTROLLING OR INHIBITING CELL-ADHESION; PLATELET ANTIAGGREGATION WITHOUT LONG HEMORRHAGING; ANTIICHEMIC AGENTS; ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 1999-08-10 | — | — | US | disclosed |
| US-5876756-A | SUSTAINED RELEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-02 | — | — | US | disclosed |
| EP-0822931-A1 | PIPERAZINONES USEFUL AS INHIBITORS OF PLATELET AGGREGATION | Takeda Chemical Industries, Ltd. (JP) | 1998-02-11 | — | — | EP | disclosed |
| EP-0765660-A2 | Microcapsules comprising 2-piperazinone-1-acetic acid compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-02 | — | — | EP | disclosed |
| WO-1996033982-A1 | PIPERAZINONES USEFUL AS INHIBITORS OF PLATELET AGGREGATION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-31 | — | — | WO | disclosed |