Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277721 | 0.93 | NR1H2 (0.70) | NR1H2ESR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7277087 | 0.88 | ESR2 (0.57) | NR1H2ESR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26596774 | 0.86 | ESR2 (0.57) | NR1H2ESR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2307305 | 0.85 | ESR2 (0.60) | NR1H2ESR2NPC1RAB9AESR1 | |
| SCHEMBL9257638 | 0.82 | ESR2 (0.56) | NR1H2ESR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3892320 | 0.82 | ESR2 (0.56) | NR1H2ESR2NPC1RAB9AGPR119 | |
| SCHEMBL4039631 | 0.82 | ESR2 (0.56) | NR1H2ESR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9052660 | 0.82 | NR1H2 (0.61) | NR1H2ESR2NPC1RAB9AGPR119 | |
| SCHEMBL2306894 | 0.81 | NR1H2 (0.85) | NR1H2ESR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4917789 | 0.81 | ESR2 (0.55) | NR1H2ESR2NPC1RAB9AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528369-B1 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-11-24 | — | — | EP | disclosed |
| EP-0528369-A2 | Cyclic imino derivatives, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-02-24 | — | — | EP | disclosed |