Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.42 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294032 | 0.93 | BCHE (0.49) | BCHEACHEALBMCHR1 | |
| SCHEMBL7286561 | 0.84 | PARP1 (0.45) | BRD4BCHEACHEBRD2BRD3 | |
| SCHEMBL7282759 | 0.83 | PARP10 (0.44) | BRD4BCHEACHEBRD2BRD3 | |
| SCHEMBL7291788 | 0.82 | RIPK3 (0.42) | BRD4BCHEACHEBRD2BRD3 | |
| SCHEMBL7285287 | 0.81 | CYP19A1 (0.49) | BRD4BCHEACHEBRD2BRD3 | |
| SCHEMBL7294670 | 0.80 | PARP10 (0.50) | BRD4BCHEACHEBRD2BRD3 | |
| SCHEMBL7302751 | 0.80 | BRD4 (0.40) | BRD4BCHEACHEBRD2BRD3 | |
| SCHEMBL7283870 | 0.79 | CDC7 (0.39) | BRD4BCHEACHECDC7PKN1 | |
| SCHEMBL7285389 | 0.78 | JAK2 (0.38) | BRD4CREBBPJAK2BTKPARP1 | |
| SCHEMBL918 | 0.76 | BRD4 (0.57) | BRD4BCHEACHEBRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353983-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1996-05-29 | — | — | EP | disclosed |
| US-5183820-A | Useful for treatment of nausea, vomiting, irritable bowel syndrome and dyspepsia | GLAXO GROUP LIMITED (GB) | 1993-02-02 | — | — | US | disclosed |
| EP-0353983-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-02-07 | — | — | EP | disclosed |