Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294032 | 0.81 | BCHE (0.49) | — | |
| SCHEMBL17895742 | 0.79 | KDM4E (0.38) | JAK2BTKBUB1KDM4ECSNK2A1 | |
| SCHEMBL7285293 | 0.79 | KDM4E (0.41) | JAK2BTKKDM4EHTR2AHTR2C | |
| SCHEMBL7285283 | 0.79 | KDM4E (0.41) | JAK2BTKKDM4EHTR2AHTR2C | |
| SCHEMBL7285339 | 0.78 | BRD4 (0.42) | JAK2BTKPARP1CREBBPBRD4 | |
| SCHEMBL6921111 | 0.76 | CSNK2A2 (0.53) | CSNK2A1CSNK2A2CSNK2BABCG2PTGS1 | |
| SCHEMBL23537658 | 0.75 | BUB1 (0.43) | BUB1KDM4EHTR2AHTR2CCSNK2A1 | |
| SCHEMBL1146660 | 0.75 | HTR2A (0.51) | BUB1KDM4EHTR2AHTR2CALDH1A1 | |
| SCHEMBL30223533 | 0.75 | HTR2A (0.51) | BUB1KDM4EHTR2AHTR2CALDH1A1 | |
| SCHEMBL29824768 | 0.75 | BUB1 (0.43) | BUB1KDM4EHTR2AHTR2CCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353983-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1996-05-29 | — | — | EP | disclosed |
| US-5202343-A | Treating anxiety, psychological disorders | GLAXO GROUP LIMITED (GB) | 1993-04-13 | — | — | US | disclosed |
| US-5183820-A | Useful for treatment of nausea, vomiting, irritable bowel syndrome and dyspepsia | GLAXO GROUP LIMITED (GB) | 1993-02-02 | — | — | US | disclosed |
| EP-0353983-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-02-07 | — | — | EP | disclosed |
| US-4859662-A | Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances | GLAXO GROUP LIMITED (GB) | 1989-08-22 | — | — | US | disclosed |