⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1814736 | 0.77 | — | — | |
| SCHEMBL1176679 | 0.72 | — | — | |
| SCHEMBL18396189 | 0.72 | — | — | |
| SCHEMBL1814739 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL5861361 | 0.70 | — | — | |
| SCHEMBL3731468 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL2702445 | 0.67 | — | — | |
| SCHEMBL899543 | 0.65 | — | — | |
| SCHEMBL87668 | 0.65 | — | — | |
| Hydrochloric Acid SCHEMBL4623997 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227092-A | Compounds and methods of use thereof for treating cancer | 亚瑞克西斯制药公司 | 2021-08-06 | — | — | CN | claimed |
| CN-113207291-A | 2- (2-acryloyl-2, 6-diazaspiro [3.4] oct-6-yl) -6- (1H-indazol-4-yl) benzonitrile derivatives and related compounds as inhibitors of G12C mutant KRAS protein for inhibiting tumor metastasis | 亚瑞克西斯制药公司 | 2021-08-03 | — | — | CN | claimed |
| CN-112584833-A | Heterocyclic spiro compounds and methods of use thereof for treating cancer | 亚瑞克西斯制药公司 | 2021-03-30 | — | — | CN | claimed |
| US-4465620-A | SURFACTANT, AMINOALKYLSULFIDE | PETROLITE CORPORATION (US) | 1984-08-14 | — | — | US | claimed |
| JP-5239096-A | — | — | None | — | — | JP | disclosed |
| US-20230016791-A1 | INHALABLE DRY POWDER AND AEROSOL FORMULATIONS OF JAK INHIBITORS | GENENTECH, INC. (US) | 2023-01-19 | — | — | US | disclosed |
| EP-3986901-A1 | PYRAZOLOPYRIMIDINE SULFONE INHIBITORS OF JAK KINASES AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2022-04-27 | — | — | EP | disclosed |
| CN-114008051-A | Pyrazolopyrimidine sulfone inhibitors of JAK kinases and uses thereof | 豪夫迈·罗氏有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-113227092-A | Compounds and methods of use thereof for treating cancer | 亚瑞克西斯制药公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-113207291-A | 2- (2-acryloyl-2, 6-diazaspiro [3.4] oct-6-yl) -6- (1H-indazol-4-yl) benzonitrile derivatives and related compounds as inhibitors of G12C mutant KRAS protein for inhibiting tumor metastasis | 亚瑞克西斯制药公司 | 2021-08-03 | — | — | CN | disclosed |
| CN-112584833-A | Heterocyclic spiro compounds and methods of use thereof for treating cancer | 亚瑞克西斯制药公司 | 2021-03-30 | — | — | CN | disclosed |
| WO-2020257145-A1 | PYRAZOLOPYRIMIDINE SULFONE INHIBITORS OF JAK KINASES AND USES THEREOF | GENENTECH, INC. (US) | 2020-12-24 | — | — | WO | disclosed |
| US-5041481-A | Curable composition comprising adhesion improver | SUNSTAR GIKEN KABUSHIKI KAISHA (JP) | 1991-08-20 | — | — | US | disclosed |
| US-4673508-A | Inhibition of calcium phosphate scale formation with a maleate polymer | MONSANTO COMPANY (US) | 1987-06-16 | — | — | US | disclosed |
| EP-0172154-A2 | Inhibition of scale formation with a maleate polymer | Monsanto Company (US) | 1986-02-19 | — | — | EP | disclosed |
| US-4465620-A | SURFACTANT, AMINOALKYLSULFIDE | PETROLITE CORPORATION (US) | 1984-08-14 | — | — | US | disclosed |
| US-4465620-A | SURFACTANT, AMINOALKYLSULFIDE | PETROLITE CORPORATION (US) | 1984-08-14 | — | — | US | disclosed |
| US-4415591-A | MIXTURE WITH A MONOAMINE OXIDASE | GEORGIA TECH RESEARCH INSTITUTE (US) | 1983-11-15 | — | — | US | disclosed |
| US-4281118-A | Aminoalkylsulfides, aminoalkylsulfoxides, and aminoalkylsulfones | THE DOW CHEMICAL COMPANY (US) | 1981-07-28 | — | — | US | disclosed |
| US-4281118-A | Aminoalkylsulfides, aminoalkylsulfoxides, and aminoalkylsulfones | THE DOW CHEMICAL COMPANY (US) | 1981-07-28 | — | — | US | disclosed |