Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8882305 | 0.81 | HTT (0.38) | JAK2JAK1ALDH1A1NPC1SIGMAR1 | |
| SCHEMBL7293030 | 0.80 | JAK2 (0.43) | JAK2JAK1HSD11B1STSRAB9A | |
| SCHEMBL4121758 | 0.78 | SMN1; SMN2 (0.57) | STSNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7480840 | 0.78 | ACHE (0.52) | ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL24126275 | 0.77 | AKT1 (0.43) | JAK2JAK1HSD11B1ALDH1A1CTSL | |
| SCHEMBL8416981 | 0.77 | AKT1 (0.43) | JAK2JAK1HSD11B1ALDH1A1CTSL | |
| SCHEMBL15707864 | 0.77 | AKT1 (0.43) | JAK2JAK1HSD11B1ALDH1A1CTSL | |
| SCHEMBL8993974 | 0.76 | SMN1; SMN2 (0.54) | STSNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL18551726 | 0.74 | SMN1; SMN2 (0.52) | JAK2JAK1STSNPC1RAB9A | |
| SCHEMBL29060009 | 0.74 | SMN1; SMN2 (0.52) | JAK2JAK1STSNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0505868-B1 | N-Acyl-alpha-aminoacids derivatives | HOFFMANN LA ROCHE (CH) | 1995-09-13 | — | — | EP | disclosed |
| EP-0505868-A2 | N-Acyl-alpha-aminoacids derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-09-30 | — | — | EP | disclosed |