Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 3/20 | 0.51 |
| ▸ | ELANE | P08246 | 13/20 | 0.51 |
| ▸ | CMA1 | P23946 | 1/20 | 0.50 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13814740 | 0.84 | ELANE (0.53) | CAPN1ELANECMA1MALT1 | |
| SCHEMBL7278810 | 0.84 | ELANE (0.52) | CAPN1ELANECMA1MALT1CCR1 | |
| SCHEMBL10081595 | 0.82 | ELANE (0.65) | ELANECMA1 | |
| SCHEMBL10081596 | 0.81 | ELANE (0.57) | CAPN1ELANECMA1 | |
| SCHEMBL17425092 | 0.81 | CMA1 (0.56) | CAPN1ELANECMA1CCR1 | |
| SCHEMBL1506200 | 0.81 | ALDH1A1 (0.62) | CAPN1ELANECMA1CCR1 | |
| SCHEMBL22209363 | 0.81 | ALDH1A1 (0.62) | CAPN1ELANECMA1CCR1 | |
| SCHEMBL30051146 | 0.81 | ALDH1A1 (0.62) | CAPN1ELANECMA1CCR1 | |
| SCHEMBL1506251 | 0.81 | ACE (0.61) | CAPN1ELANECMA1CCR1 | |
| SCHEMBL10063674 | 0.81 | ACE (0.61) | CAPN1ELANECMA1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |