Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 9/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 7/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 7/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 7/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 7/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286395 | 1.00 | GRIN2B (0.59) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7286810 | 0.79 | MAPT (0.55) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL21651971 | 0.74 | GRIN2B (0.59) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7295407 | 0.74 | GRIN2B (1.00) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL27439499 | 0.74 | GRIN2B (0.60) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7288840 | 0.73 | GRIN2B (0.98) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL499394 | 0.73 | GRIN2D (1.00) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7288999 | 0.72 | GRIN2B (0.58) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL1994218 | 0.72 | GRIN2D (0.98) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL15759176 | 0.72 | LTA4H (0.63) | ADRA1AADRA1DLTA4HALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824098-B1 | 4-hydroxy-piperidine derivatives | HOFFMANN LA ROCHE (CH) | 2001-10-31 | — | — | EP | disclosed |
| EP-0824098-A1 | 4-hydroxy-piperidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-18 | — | — | EP | disclosed |