Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.51 |
| ▸ | ADH5 | P11766 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290491 | 0.80 | PDE3B (0.57) | PDE3BPDE3AADH5RAB9ASMN1; SMN2 | |
| SCHEMBL11245497 | 0.80 | MAPT (0.50) | SMN1; SMN2ALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL11399679 | 0.76 | KDM4E (0.58) | KMT2ATSHRMEN1HRH3LMNA | |
| SCHEMBL3839136 | 0.75 | KDM4E (0.60) | KMT2ATSHRMEN1ALOX15CYP3A4 | |
| SCHEMBL11395281 | 0.74 | KDM4E (0.50) | SMN1; SMN2ALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL11249160 | 0.72 | MAPT (0.48) | KMT2ATSHRMEN1HRH3PDE4A | |
| SCHEMBL11242297 | 0.70 | MAPT (0.47) | KMT2ATSHRMEN1HRH3PDE4A | |
| SCHEMBL11401220 | 0.69 | SCN4A (0.52) | SMN1; SMN2ALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL11403350 | 0.69 | TSHR (0.54) | SMN1; SMN2ALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL2533488 | 0.69 | TSHR (0.84) | PDE3BPDE3AADH5RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | disclosed |
| US-4353905-A | CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1982-10-12 | — | — | US | disclosed |