Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | ADH5 | P11766 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286953 | 0.80 | PDE3B (0.51) | PDE3BPDE3ARAB9AHRH3NPC1 | |
| SCHEMBL11231804 | 0.76 | HRH3 (0.51) | HRH3MAPT | |
| SCHEMBL2533488 | 0.74 | TSHR (0.84) | PDE3BPDE3ARAB9ANPC1KMT2A | |
| SCHEMBL7280366 | 0.72 | PDE3B (1.00) | PDE3BPDE3ARAB9ANPC1KMT2A | |
| SCHEMBL5287962 | 0.72 | HRH3 (0.51) | RAB9AHRH3NPC1KMT2AMEN1 | |
| SCHEMBL3098258 | 0.72 | PDE3B (0.50) | PDE3BPDE3AHRH3 | |
| SCHEMBL3097596 | 0.72 | HRH3 (0.45) | PDE3BPDE3AHRH3 | |
| SCHEMBL2532397 | 0.72 | LMNA (0.78) | KMT2ATSHRMEN1ALOX15ADH5 | |
| SCHEMBL11397967 | 0.72 | HRH3 (0.54) | RAB9AHRH3KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3089686 | 0.72 | HRH3 (0.54) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | claimed |
| US-4353905-A | CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1982-10-12 | — | — | US | disclosed |