SCHEMBL728713

SCHEMBL728713

N[C@@H]1CCCCN(c2c(F)cc3c(c2Cl)N(C2CC2)CC(C(=O)O)C3=O)C1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.45
POLB P06746 1/20 0.45
CHRM2 P08172 1/20 0.45
CHRM1 P11229 1/20 0.45
OPRM1 P35372 1/20 0.45
OPRD1 P41143 1/20 0.45
DPP4 P27487 2/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
MAP4K1 Q92918 1/20 0.33
TOP2A P11388 9/20 0.33
TOP2B Q02880 7/20 0.33
PIM1 P11309 1/20 0.33
GSK3A P49840 1/20 0.33
GSK3B P49841 1/20 0.33
PIM3 Q86V86 1/20 0.33
CSNK1G1 Q9HCP0 1/20 0.33
TOP1 P11387 2/20 0.32
PIM2 Q9P1W9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12820265 0.93 ALDH1A1 (0.52) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL8775774 0.79 ALDH1A1 (0.32) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL10430087 0.73 ALDH1A1 (0.51) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL12553998 0.70 ALDH1A1 (0.42) ALDH1A1POLBCHRM2CHRM1OPRM1
Besifloxacin SCHEMBL725805 0.70 ALDH1A1 (0.88) ALDH1A1POLBCHRM2CHRM1OPRM1
Besifloxacin SCHEMBL725804 0.70 ALDH1A1 (0.88) ALDH1A1POLBCHRM2CHRM1OPRM1
Besifloxacin SCHEMBL5959095 0.70 ALDH1A1 (0.88) ALDH1A1POLBCHRM2CHRM1OPRM1
Besifloxacin SCHEMBL291598 0.69 ALDH1A1 (0.86) ALDH1A1POLBCHRM2CHRM1OPRM1
Besifloxacin SCHEMBL29359545 0.69 ALDH1A1 (0.86) ALDH1A1POLBCHRM2CHRM1OPRM1
Besifloxacin SCHEMBL28011379 0.69 ALDH1A1 (0.86) ALDH1A1POLBCHRM2CHRM1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011162951-A1 COMPOSITIONS AND METHODS FOR ENHANCING REDUCTION OF SPORE-FORMING MICROORGANISM BAUSCH & LOMB INCORPORATED (US) 2011-12-29 WO disclosed