Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.46 |
| ▸ | METAP2 | P50579 | 10/20 | 0.37 |
| ▸ | METAP1 | P53582 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275433 | 1.00 | REN (0.46) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7275426 | 1.00 | REN (0.46) | RENMETAP2METAP1ALDH1A1KMT2A | |
| Acetic Acid SCHEMBL7284468 | 0.93 | REN (0.44) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL10591623 | 0.88 | REN (0.46) | RENMETAP2METAP1 | |
| SCHEMBL7274058 | 0.88 | REN (0.49) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL6682408 | 0.85 | REN (0.49) | RENMETAP2METAP1 | |
| SCHEMBL9556161 | 0.85 | REN (0.49) | RENMETAP2METAP1 | |
| SCHEMBL9472371 | 0.85 | REN (0.49) | RENMETAP2METAP1 | |
| SCHEMBL9417458 | 0.85 | REN (0.49) | RENMETAP2METAP1 | |
| SCHEMBL7265179 | 0.85 | REN (0.49) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307837-A2 | Renin-inhibiting peptidyl heterocycles | ABBOTT LABORATORIES (US) | 1989-03-22 | — | — | EP | disclosed |