Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 4/20 | 0.59 |
| ▸ | BACE1 | P56817 | 4/20 | 0.59 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871560 | 1.00 | LCK (0.60) | LCKGSK3BBACE1PPARGRAB9A | |
| SCHEMBL14786203 | 0.86 | LCK (0.77) | LCKGSK3BBACE1PPARGRAB9A | |
| SCHEMBL20024692 | 0.86 | LCK (0.77) | LCKGSK3BBACE1PPARGRAB9A | |
| SCHEMBL14691485 | 0.85 | LCK (0.62) | LCKGSK3BBACE1PPARGRAB9A | |
| SCHEMBL8913578 | 0.84 | LCK (0.81) | LCKGSK3BBACE1PPARGRAB9A | |
| SCHEMBL8913590 | 0.84 | LCK (0.81) | LCKGSK3BBACE1PPARGRAB9A | |
| SCHEMBL10953300 | 0.83 | GSK3B (0.63) | LCKGSK3BBACE1PPARGRAB9A | |
| SCHEMBL10953297 | 0.83 | GSK3B (0.63) | LCKGSK3BBACE1PPARGRAB9A | |
| SCHEMBL7295487 | 0.83 | LCK (0.68) | LCKSMN1; SMN2LMNAMAOBMAOA | |
| SCHEMBL9870855 | 0.83 | LCK (0.68) | LCKSMN1; SMN2LMNAMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347766-B1 | 4,5,7,8-Tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as medicaments | THOMAE GMBH DR K (DE) | 1994-05-25 | — | — | EP | disclosed |
| US-5068325-A | Dopaminergic systems as hypotensives, sedatives, antitussives and/or antiphlogistics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |
| EP-0347766-A2 | 4,5,7,8-Tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as medicaments | Dr. Karl Thomae GmbH (DE) | 1989-12-27 | — | — | EP | disclosed |
| EP-0071399-A2 | Substituted pyrrolidine cardiovascular system regulators and antihypertensives, their preparation and use | SYNTEX (U.S.A.) INC. (US) | 1983-02-09 | — | — | EP | disclosed |