Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
| ▸ | CDK4 | P11802 | 1/20 | 0.65 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.65 |
| ▸ | CCND1 | P24385 | 1/20 | 0.65 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 8/20 | 0.63 |
| ▸ | MAOA | P21397 | 5/20 | 0.63 |
| ▸ | TLR4 | O00206 | 3/20 | 0.60 |
| ▸ | TLR2 | O60603 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295487 | 1.00 | LCK (0.68) | LCKCCNB2CDK1CDK4CCNB1 | |
| SCHEMBL14691654 | 0.86 | LCK (0.70) | LCKCCNB2CDK1CDK4CCNB1 | |
| SCHEMBL15008587 | 0.85 | LCK (0.68) | LCKCCNB2CDK1CDK4CCNB1 | |
| SCHEMBL15008588 | 0.85 | LCK (0.68) | LCKCCNB2CDK1CDK4CCNB1 | |
| SCHEMBL15018330 | 0.85 | LCK (0.68) | LCKCCNB2CDK1CDK4CCNB1 | |
| SCHEMBL9871560 | 0.83 | LCK (0.60) | LCKKDM4EMAOBMAOALMNA | |
| SCHEMBL7287757 | 0.83 | LCK (0.60) | LCKKDM4EMAOBMAOALMNA | |
| SCHEMBL17821810 | 0.83 | LCK (0.74) | LCKCCNB2CDK1CDK4CCNB1 | |
| SCHEMBL17821808 | 0.83 | LCK (0.74) | LCKCCNB2CDK1CDK4CCNB1 | |
| SCHEMBL9434803 | 0.81 | LCK (0.72) | LCKCCNB2CDK1CDK4CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068325-A | Dopaminergic systems as hypotensives, sedatives, antitussives and/or antiphlogistics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |