Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279320 | 0.84 | PRKCI (0.39) | PRKCIMAPTALDH1A1KDM4EALOX15 | |
| SCHEMBL9772348 | 0.78 | PRKCI (0.45) | PRKCIMAPTALDH1A1KDM4EALOX15 | |
| SCHEMBL3141353 | 0.75 | TLR8 (0.46) | PRKCIMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL8331398 | 0.75 | PRKCI (0.46) | PRKCIMAPTALDH1A1KDM4EALOX15 | |
| SCHEMBL20348785 | 0.75 | PRKCI (0.46) | PRKCIMAPTALDH1A1KDM4EAPEX1 | |
| SCHEMBL14958647 | 0.73 | TLR8 (0.45) | PRKCIMAPTALDH1A1KDM4EALOX15 | |
| SCHEMBL9659665 | 0.71 | PRKCI (0.43) | PRKCITDP1 | |
| SCHEMBL11489950 | 0.70 | ALDH1A1 (0.43) | PRKCIMAPTALDH1A1KDM4EALOX15 | |
| SCHEMBL9877153 | 0.69 | PRKCI (0.39) | PRKCIMAPTALDH1A1KDM4EALOX15 | |
| SCHEMBL11489947 | 0.69 | PRKCI (0.39) | PRKCIMAPTALDH1A1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021436-A | Antiulcer, anticoagulant, antiischaemic agent | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1991-06-04 | — | — | US | disclosed |
| US-4999362-A | Hypotensive, Antiulcer, Cytoprotective, Antithrombotic Agents | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1991-03-12 | — | — | US | disclosed |
| US-4918087-A | 2-thiomethyl-substituted-pyridine and -3,5-dicarboxylates having anti-hypertensive activity | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1990-04-17 | — | — | US | disclosed |
| EP-0282904-A2 | 2-Thiomethyl-substituted-pyridines, a method for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1988-09-21 | — | — | EP | disclosed |
| EP-0233228-A1 | PHARMACEUTICALLY ACTIVE 2-THIOMETHYL-SUBSTITUTED-1,4-DIHYDROPYRIDINES | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1987-08-26 | — | — | EP | disclosed |
| WO-1987000836-A1 | PHARMACEUTICALLY ACTIVE 2-THIOMETHYL-SUBSTITUTED-1,4-DIHYDROPYRIDINES | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1987-02-12 | — | — | WO | disclosed |